Endocrine Abstracts

Type I phosphoinositide 3-kinases (PI3Ks)are regulated by tyrosine kinases, Ras and G-protein coupled receptors and generate the lipid second messenger, phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 regulates a bewildering variety of cellular responses primarily through binding and hence activating or targeting a range of proteins each of which posseses a specific PIP3 binding module, most commonly a pleckstrin homology (PH) domain. In terms of cell survival the key ...